Backup the file that you’re about to patch:

sudo cp /System/Library/Extensions/IOAHCIFamily.kext/Contents/PlugIns/IOAHCIBlockStorage.kext/Contents/MacOS/IOAHCIBlockStorage /IOAHCIBlockStorage.original

Patch the file to enable TRIM support:

sudo perl -pi -e ‘s|(\x52\x6F\x74\x61\x74\x69\x6F\x6E\x61\x6C\x00).{9}(\x00\x51)|$1\x00\x00\x00\x00\x00\x00\x00\x00\x00$2|sg’ /System/Library/Extensions/IOAHCIFamily.kext/Contents/PlugIns/IOAHCIBlockStorage.kext/Contents/MacOS/IOAHCIBlockStorage

Clear the kext caches:

sudo kextcache -system-prelinked-kernel
sudo kextcache -system-caches

Important: reboot your Mac!